Hormone Replacement Therapy (HRT)

2007-04-30T11:24:00.000+01:00

This review is a pragmatic attempt to highlight recent research and background material in migraine. It should not be considered exhaustive, simply a way of reviewing some of the major developments and current thinking in the area.

TRIP have created another review dealing with the menopause, this has a different focus, but contains some of the material below and may be of interest.

Click here to see all the TRIP Evidence Reviews.

Evidence-Based Reports

Hormone replacement therapy: an update. MeReC, 2005
No long-term benefit shown for bones after HRT. POEMs, 2005
Postmenopausal oestrogen does not improve cognitive function. POEMs, 2005
Oestrogen plus progestin reduced risk of fracture in postmenopausal women. Evidence-Based Medicine (Requires free registration), 2005
Oestrogen plus progestogen did not prevent cardiovascular disease in postmenopausal women. Evidence-Based Nursing (Requires free registration), 2005
Hormones, thrombophilia, and VTE. Bandolier, 2006
Hormone Replacement Therapy. British Menopause Society Consensus Statements, 2006
HRT and tibolone (Livial): update on the risk of endometrial cancer. Medicines and Healthcare products Regulatory Agency, 2006

Clinical Guidelines

Canadian Consensus Conference on Menopause. Society of Obstetricians and Gynaecologists of Canada, 2006
Hormone therapy for the prevention of chronic conditions in postmenopausal women: recommendation statement. U.S. Preventive Services Task Force, 2005
Menopause: a guide to management. Brigham and Women's Hospital, 2005
Hormone Replacement Therapy and Venous Thromboembolism. Royal College of Obstetricians and Gynaecologists, 2004
Women's health and the menopause - RCN guidance for nurses, midwives and health visitors. Royal College of Nursing, 2005
Menopause. PRODIGY, 2005
Hormone Replacement Therapy. New Zealand Guidelines Group, 2004

Systematic Reviews

Effect of oral contraceptives and hormone replacement therapy on bone mineral density in premenopausal and perimenopausal women: a systematic review. DARE, 2006
Reassessment of the cost-effectiveness of hormone replacement therapy in Sweden: results based on the Women's Health Initiative randomized controlled trial. NHS Economic Evaluation Database, 2005
Hormone replacement therapy for preventing cardiovascular disease in post-menopausal women. Cochrane Database of Systematic Reviews, 2005
Cost-effectiveness of osteoporosis screening and treatment with hormone replacement therapy raloxifene, or alendronate. NHS EED, 2006
Transdermal hormone replacement therapy patches for women with postmenopausal symptoms: economic analysis of short-term use. HTA, 2006
Management of Menopause-Related Symptoms. NIH Consensus Statements, 2005
Local oestrogen for vaginal atrophy in postmenopausal women. Cochrane Database of Systematic Reviews, 2006

Recent articles from core journals

Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA, 2007
Effect of hormone therapy on risk of hip and knee joint replacement in the women`s health initiative. Arthritis Rheum, 2006
Association between hormone replacement therapy and subsequent stroke: a meta-analysis. BMJ, 2005
The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Annals of Internal Medicine, 2005

eTextbooks

Clinical Queries

For a women with very low libido what hormone replacement therapy (HRT) is advised is terms of best balance? FFPRHC, 2007
What is the current evidence concerning the use of hormone replacement therapy in a woman with breast cancer? FFPRHC, 2007
Regarding HRT- Is anyone aware of any changes to the advice? NLH Q&A Service, 2007
In patients with premature menopause age of 40 is it still appropriate to prescribe HRT to prevent osteoporosis? NLH Q&A Service, 2007

Patient Information

Ongoing Research

Important links to two major research initiatives investigating health in postmenopausal. The study of HRT is a significant part of both studies. Both report on latest findings.

Women’s Health Initiative (USA)
The Million Women Study (UK)

TRIP Evidence Reviews: Hormone Replacement Therapy

Hormone Replacement Therapy (HRT)